Mikusek, JiriNugent, JeremyLan, PingBanwell, Martin2019-06-200163-3864http://hdl.handle.net/1885/164117In 2002, Hirota and co-workers reported(1) the isolation and structural elucidation of a series of anti-inflammatory agents, named myrsinoic acids, from the fresh leaves and twigs of Myrsine seguinii, a hardwood of the Myrsinaceae family found in various parts of Asia from Myanmar to Japan. The most active of these compounds was myrsinoic acid F (MA-F) and to which structure 1 (Figure 1) was assigned(1) on the basis of a range of NMR spectroscopic and mass spectrometric studies. This compound and various structurally related co-metabolites have since been encountered in certain other plants (e.g., Rapanea ferruginea and Myrsine coriacea) found in several parts of the globe, and a number of these have been shown to exhibit potentially useful biological properties including selective cytotoxic, anti-microbial, and anti-leishmanial effects.(2) The anti-inflammatory properties of these compounds may arise through their inhibition of DNA polymerase λ.(3)We thank the Australian Research Council, the Institute of Advanced Studies, Jinan University, the Pearl River Scholar Program of Guangdong Province, and the Famous Foreign Supervisor Program (Grant 2018-HWMS001) of the Ministry of Education, People’s Republic of China for financial support.application/pdfen-AU© 2018 American Chemical Society and American Society of Pharmacognosy201910.1021/acs.jnatprod.8b007782019-03-24