Novel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy

Jackson, RonaldWorley, MatthewTrivedi, ShubhanshiRanasinghe, Charani2015-12-130264-410Xhttp://hdl.handle.net/1885/75958We have established that the efficacy of a heterologous poxvirus vectored HIV vaccine, fowlpox virus (FPV)-HIV gag/pol prime followed by attenuated vaccinia virus (VV)-HIV gag/pol booster immunisation, is strongly influenced by the cytokine milieu at theNovel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy201410.1016/j.vaccine.2014.08.0232015-12-11