de Jersey, JamesSnelgrove, Sarah LPalmer, StephanieTeteris, SimonMullbacher, ArnoMiller, JacquesSlattery, Robyn2015-12-070027-8424http://hdl.handle.net/1885/21797Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet β cells. CD8 T cells are prevalent in the islets of T1D patients and are the major effectors of β cell destruction in nonobese diabetic (NOD) mice. In addition to their criticKeywords: beta 2 microglobulin; animal cell; animal experiment; animal model; antigen expression; antigen presenting cell; article; autoimmunity; CD8+ T lymphocyte; controlled study; female; flow cytometry; gene inactivation; gene targeting; insulin dependent diabe Antigen-presenting cells; Autoimmunity; Insulitis; Type 1 diabetes200710.1073/pnas.06100571042015-12-07