Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy

Blery, MathieuTze, LinaMiosge, LisaJun, JesseGoodnow, Christopher2015-12-130022-1007http://hdl.handle.net/1885/78666Divergent hypotheses exist to explain how signaling by the B cell receptor (BCR) is initiated after antigen binding and how it is qualitatively altered in anergic B cells to selectively uncouple from nuclear factor κB and c-Jun N-terminal kinase pathwaysKeywords: B lymphocyte receptor; cholesterol; immunoglobulin D; immunoglobulin enhancer binding protein; methyl beta cyclodextrin; sphingolipid; stress activated protein kinase; animal cell; animal experiment; antigen binding; article; B lymphocyte; cell membrane;Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy200610.1084/jem.200605522015-12-11