French, Amanda N.Ashby, Regan S.Morgan, Ian G.Rose, Kathryn A.2013-10-092013-10-090014-48351096-0007http://hdl.handle.net/1885/10597Recent epidemiological evidence suggests that children who spend more time outdoors are less likely to be, or to become myopic, irrespective of how much near work they do, or whether their parents are myopic. It is currently uncertain if time outdoors also blocks progression of myopia. It has been suggested that the mechanism of the protective effect of time outdoors involves light-stimulated release of dopamine from the retina, since increased dopamine release appears to inhibit increased axial elongation, which is the structural basis of myopia. This hypothesis has been supported by animal experiments which have replicated the protective effects of bright light against the development of myopia under laboratory conditions, and have shown that the effect is, at least in part, mediated by dopamine, since the D2-dopamine antagonist spiperone reduces the protective effect. There are some inconsistencies in the evidence, most notably the limited inhibition by bright light under laboratory conditions of lens-induced myopia in monkeys, but other proposed mechanisms possibly associated with time outdoors such as relaxed accommodation, more uniform dioptric space, increased pupil constriction, exposure to UV light, changes in the spectral composition of visible light, or increased physical activity have little epidemiological or experimental support. Irrespective of the mechanisms involved, clinical trials are now underway to reduce the development of myopia in children by increasing the amount of time they spend outdoors. These trials would benefit from more precise definition of thresholds for protection in terms of intensity and duration of light exposures. These can be investigated in animal experiments in appropriate models, and can also be determined in epidemiological studies, although more precise measurement of exposures than those currently provided by questionnaires is desirable.11 pageshttp://www.sherpa.ac.uk/romeo/issn/0014-4835/ Pre-print allowed on any open access repository. Post-print allowed on institutional repository, if the deposit is voluntary. Author cannot archive Publisher's Version/PDF. Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between body and the publisher exists. If mandated deposit is permitted through a publisher agreement, embargo periods of 12 months to 48 months may apply. Set statement to accompany deposit. Published source must be acknowledged. Must link to journal home page or articles' DOI - from SHERPA/RoMEO site (as at 5/12/13)myopiaincident myopiamyopia progressionpreventionoutdoorslightdopaminespiperoneclinical trial2013-0910.1016/j.exer.2013.04.0182015-12-11