Tan, Siu MinWillis, Anthony CPaddon-Row, Michael NSherburn, Michael2018-11-162018-11-16http://hdl.handle.net/1885/1495381-Aminodecalins were prepared from acyclic precursors by combining the powerful twofold diene-transmissive Diels-Alder chemistry of [3]dendralenes with the simplicity of enamine formation. On mixing at ambient temperature, a simple dienal condenses with a primary or secondary amine to generate the enamine, a 1-amino-[3]dendralene in situ, and this participates as a double diene in a sequence of two Diels-Alder events with separate dienophiles. Overall, four C-C bonds and one C-N bond are formed. Mechanistic insights into these reactions are provided by means of density functional theory calculations.application/pdfdiels-alder reactionsdensity functional calculationsdomino reactionsmulticomponent reactionspolycycles2016-02-2410.1002/anie.201510925