Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases

Lim, CindyMatthaei, KlausBlackburn, AnnekeDavis, RichardKoina, MarkAnders, MichaelBoard, PhilipDahlstrom, Jane2015-12-130002-9440http://hdl.handle.net/1885/87448Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of α-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water. GSTZ1-1 is identical with maleylacetoacetate isomerase, which catalyzesKeywords: dichloroacetic acid; glutathione transferase; glutathione transferase alpha; glutathione transferase zeta; isomerase; maleylacetoacetate isomerase; mu glutathione transferase; oxidoreductase; phenylalanine; pi glutathione transferase; quinone oxidoreductaMice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases20042015-12-12