Bernardo, PaulChai, ChristinaDeeble, GeoffreyLiu, XiWaring, Paul2015-12-100960-894Xhttp://hdl.handle.net/1885/62519The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.Keywords: gliotoxin; glutathione; article; drug conjugation; drug mechanism; drug structure; equilibrium constant; high performance liquid chromatography; nuclear magnetic resonance spectroscopy; pH; reaction analysis; Chromatography, High Pressure Liquid; Gliotoxi200110.1016/S0960-894X(00)00696-X2015-12-10