Mudianta, WayanKatavic, Peter LLambert, Lynette KHayes, Patricia YBanwell, MartinMunro, Murray HGBernhardt, PaulGarson, Mary J2015-12-070040-4020http://hdl.handle.net/1885/22474Chemical analysis of an Indonesian sponge sample has provided three new 3-alkylpiperidine alkaloids, tetradehydrohaliclonacyclamine A, its mono-N-oxide derivative, and a 2-epi isomer. The absolute structure of tetradehydrohaliclonacyclamine A has been established by X-ray crystallography from anomalous dispersion effects using Cu radiation, which determined that the absolute configuration is 2S, 3S, 7S, 9S while an HPLC study revealed that the alkaloid is enantiomerically pure.Keywords: alkaloid derivative; alkyl group; copper; piperidine derivative; tetradehydrohaliclonacyclamine a; unclassified drug; article; drug structure; enantiomer; halichondria; high performance liquid chromatography; Indonesia; irradiation; isomer; nonhuman; nucl 3-Alkylpiperidine; Absolute configuration; Biosynthesis; Halichondria; N-Oxide; NMR; Sponge; X-ray analysis201010.1016/j.tet.2010.01.0682016-02-24