Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation

Wood, RobertHulett, Mark2015-12-080021-9258http://hdl.handle.net/1885/33038Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate, an important structural component of the extracellular matrix (ECM) and vascular basement membrane (BM). The cleavage of heparan sulfate by heparanase-expressing cells, such as activatedKeywords: Adhesion; Cell adhesion; Cell culture; Cell membranes; Cytology; Degradation; Electric discharge machining; Endothelial cells; Enzyme inhibition; Pathology; Positive ions; Tumors; Acidic ph; Angiogenesis; Basement membranes; Cell invasions; Cell lines; CeCell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation200810.1074/jbc.M7087232002015-12-08