Freeman, CraigKnox, KarenBell, JessicaLobov, SergeyKing, DavidSenden, TimothyStephens, RossParish, Christopher2015-12-130142-9612http://hdl.handle.net/1885/72692Recent findings on the role of circulating histone proteins in mediating acute lung injury prompted us to investigate whether there is a specific mechanism for accumulation of histones in the lungs. Binding sites for polycations are already known in the vKeywords: Acute lung injury; Biodistributions; Charge interactions; Heparan sulphate; Histones; Intravenous injections; Lung endothelium; Positively charged; Amino acids; Biological organs; Blood vessels; Imaging techniques; Sulfur compounds; Proteins; heparan sulf Acute lung injury; Heparan sulphate; Histones; Lung endothelium201310.1016/j.biomaterials.2013.03.0912016-02-24