Ewart, GaryNasr, NajlaNaif, HassanCox, GraemeCunningham, AnthonyGage, Peter2015-12-130066-4804http://hdl.handle.net/1885/85972We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.Keywords: 5 (n,n dimethyl)amiloride; 5 (n,n hexamethylene)amiloride; amiloride derivative; anti human immunodeficiency virus agent; antigen p24; virus DNA; virus RNA; Vpu protein; antiviral activity; article; cell survival; concentration response; HeLa cell; human;200410.1128/AAC.48.6.2325-2330.20042015-12-12