Synthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore

Barker, DavidBrimble, Margaret AMcLeod, Malcolm2015-12-100040-4020http://hdl.handle.net/1885/53091The synthesis of several A and AE ring analogues of the alkaloid methyllycaconitine is reported. The key 2-(2″-methylsuccinimido)benzoate ester pharmacophore is introduced using an efficient two step procedure. Esterification of the alcohol precursors wKeywords: 2 (2'' methylsuccinimido)benzoate; acid anhydride; alkaloid derivative; anthranilic acid; benzoic acid derivative; methyllycaconitine; sodium borohydride; trifluoroacetic acid; unclassified drug; Aconitum; article; drug structure; drug synthesis; esterifi Alkaloids; Anthranilate esters; Methyllycaconitine; Nicotinic acetylcholine receptorsSynthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore200410.1016/j.tet.2004.05.0242015-12-09