Allison, StephenLooi, Jeffrey C.L.Kisely, SteveBastiampillai, Tarun2025-12-232025-12-231039-8562PubMed:39243162ORCID:/0000-0003-3351-6911/work/192699573https://hdl.handle.net/1885/733796924The Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines on mood disorders recommend psychotherapy as foundational care for patients with acute depression with minimal discussion of any potential adverse effects. Randomised controlled trial evidence on psychotherapy adverse effects is limited. This is problematic because clinicians must balance the benefits of treatment against the harms, and clinical decisions become skewed without data on adverse effects. We suggest that clinical practice guidelines should be more guarded about recommending psychotherapy and add consensus statements on adverse effects for informed consent and clinical decision-making.3enPublisher Copyright: © The Royal Australian and New Zealand College of Psychiatrists 2024.adverse effectsclinical practice guidelinesdepressive disorderspsychotherapy202510.1177/1039856224128273685203449043