Comparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases

Oakeshott, John GrahamDevonshire, AlanClaudianos, CharlesSutherland, Tara DHorne, IreneCampbell, Peter MOllis, DavidRussell, Robyn2015-12-130009-2797http://hdl.handle.net/1885/82282Mutant insect carboxyl/cholinesterases underlie over 60 cases of resistance to organophosphorus and/or carbamate insecticides. Biochemical and molecular data on about 20 of these show recurrent use of a very small number of mutational options to generateKeywords: bacterial enzyme; carbamate insecticide; carboxylesterase; cholinesterase; organophosphorus compound; chemical analysis; comparative study; conference paper; detoxification; enzyme kinetics; eukaryote; gene mutation; genetic code; genetics; insecticide re Acetylcholinesterase; Carboxylesterase; Insecticide resistance; Metabolism; Mutation; Target siteComparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases200510.1016/j.cbi.2005.10.0412015-12-11