Rapid cascade synthesis of poly-heterocyclic architectures from indigo

Shakoori, AlirezaBremner, John BWillis, AnthonyHaritakun, RachadaKeller, Paul2015-12-100022-3263http://hdl.handle.net/1885/62258The base-induced propargylation of the dye indigo results in the rapid and unprecedented one-pot synthesis of highly functionalized representatives of the pyrazino[1,2-a:4,3-a′]diindole, pyrido[1,2-a:3,4-b′]diindole and benzo[b]indolo[1,2-h]naphthyridKeywords: Anticancer activities; Antiplasmodial activity; Heterocyclic systems; Marine natural products; Polycyclic compounds; Potential reactions; Rearrangement reactions; X-ray crystallographic analysis; Addition reactions; Bioactivity; Organic compounds; X ray cRapid cascade synthesis of poly-heterocyclic architectures from indigo201310.1021/jo401210r2016-02-24