Chemoselective Ligation Methods Based on the Concept of Native Chemical Ligation

Malins, L. R.Payne, R. J.2025-06-112025-06-1197831324420922510-5469http://www.scopus.com/inward/record.url?scp=85130760020&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733758541This chapter extends from the earlier Science of Synthesis contribution on peptide synthesis (Section 21.11) and focuses on recent developments in chemoselective ligation chemistry based on the logic of native chemical ligation. Synthetic strategies that broaden the scope and versatility of the ligation reaction and that have been widely adopted for the preparation of homogeneous peptides and proteins are highlighted. Methods enabling the efficient preparation of peptide ligation precursors are also included in this chapter.49enPublisher Copyright: © 2021 Georg Thieme Verlag. All rights reserved.acyl shiftamidescysteinedeselenizationdesulfurizationligationpeptide couplingpeptidesproteinsselenocysteinesolid-phase peptide synthesisChemoselective Ligation Methods Based on the Concept of Native Chemical Ligation202110.1055/sos-SD-121-0006685130760020