Dulhunty, AngelaBeard, NicolePouliquin, PierreKimura, Takashi2015-12-130142-4319http://hdl.handle.net/1885/85122There are many mutations in the ryanodine receptor (RyR) Ca2+ release channel that are implicated in skeletal muscle disorders and cardiac arrhythmias. More than 80 mutations in the skeletal RyR1 have been identified and linked to malignant hyperthermia,Keywords: calcium channel; calcium ion; calsequestrin; receptor subunit; ryanodine receptor; ryanodine receptor 1; ryanodine receptor 2; unclassified drug; article; calcium homeostasis; calcium signaling; calcium transport; gene overexpression; genetic disorder; ge Cardiac muscle; Cardiac RyR-linked myopathies; Inter-domain interactions; Protein-protein interactions; Ryanodine receptor calcium release channels; Skeletal muscle; Skeletal RyR-linked myopathies200610.1007/s10974-006-9086-12015-12-12