Talwar, AmishLi, RongxiaLanger, Adam J.2025-12-312025-12-311080-6040PubMed:34013876ORCID:/0000-0003-0714-654X/work/193812980https://hdl.handle.net/1885/733798070Approximately 90% of tuberculosis (TB) cases among non-US-born persons in the United States are attributable to progression of latent TB infection to TB disease. Using survival analysis, we investigated whether birthplace is associated with time to disease progression among non-US-born persons in whom TB disease developed. We derived a Cox regression model comparing differences in time to TB diagnosis after US entry among 19 birth regions, adjusting for sex, birth year, and age at entry. After adjusting for age at entry and birth year, the median time to TB diagnosis was lowest among persons from Middle Africa, 128 months (95% CI 116-146 months) for male persons and 121 months (95% CI 108-136 months) for female persons. We found time to TB diagnosis among non-US-born persons varied by birth region, which represents a prognostic indicator for progression of latent TB infection to TB disease.We thank Andrew Hill for his suggestions for data analysis; Carla A. Winston, Thomas R. Navin, Sandy P. Althomsons, Jonathan Wortham, and Kristine M. Schmit for reviewing and providing input for this manuscript; Noah Schwartz, Rebekah Stewart, Peter Cegielski, and Andrew Vernon for providing helpful feedback on the study design; and the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC for facilitating the organization of this study.9enPublisher Copyright: © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.202110.3201/eid2706.20366385106517922