Nitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding

Hart, JamesDulhunty, Angela2015-12-130022-2631http://hdl.handle.net/1885/88899We show that rabbit skeletal RyR channels in lipid bilayers can be activated or inhibited by NO, in a manner that depends on donor concentration, membrane potential and the presence of channel agonists. 10 μM S-nitroso-N-acetyl-penicillamine (SNAP) increKeywords: adenosine triphosphate; calcium channel; dithiothreitol; n acetyl s nitrosopenicillamine; nitric oxide; nitroprusside sodium; peptide; ryanodine receptor; animal tissue; article; calcium transport; channel gating; concentration response; electric potentia Calcium channels; Nitric oxide; Oxidation; Regulatory thiols; Ryanodine receptors; Skeletal MuscleNitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding200010.1007/s0023200010222015-12-12