Wilkins, Leanne KGirard, Todd AChristensen, BruceKing, JelenaKiang, MichaelBohbot, Veronique D2023-08-290165-1781http://hdl.handle.net/1885/296971Spatial memory is core to wayfinding and everyday memory. Interestingly, individuals with schizophrenia using spatial navigation strategies (cognitive mapping) are impaired, whereas those using response-based (e.g., single-landmark) strategies show relatively intact memory performance. We observed abnormal brain communication in schizophrenia participants who used a spatial strategy during a virtual-reality navigation task, particularly between temporal and frontal brain regions. In contrast, schizophrenia participants using a response strategy recruited similar brain systems to healthy participants, but to a greater extent to support memory performance. These findings highlight that strategy use is an important consideration for understanding memory systems and navigation in schizophrenia.application/pdfen-AU© 2019 The authorsSpatial memoryMagnetic resonance imagingFunctional neural networks201910.1016/j.psychres.2019.05.0322022-07-24