Farrer, LouiseGulliver, AmeliaKatruss, NatashaFassnacht, DanielKyrios, MichaelBatterham, Philip2020-12-032020-12-032214-7829http://hdl.handle.net/1885/216680Background Of the millions of students enrolled in university, up to 50% will experience a mental disorder. Many of these students do not seek help, and for those who do, university-based services are often over-burdened. Anonymous, evidence-based, online interventions can improve students' access to mental health support. The Uni Virtual Clinic (UVC) is a transdiagnostic online mental health program designed specifically for university students. This paper reports on a randomised controlled trial examining the effectiveness of the UVC in a sample of Australian university students. Methods University students with elevated psychological distress (K10>15; n = 200) were randomised to the UVC intervention or a waitlist control condition for a period of 6 weeks. Baseline, post-intervention, and 3-month follow-up surveys assessed depression, anxiety, self-efficacy, quality of life, adherence, and satisfaction with the UVC intervention. Results Mixed models analysis demonstrated that use of the UVC was associated with small significant reductions in social anxiety and small improvements in academic self-efficacy. The program was not effective in reducing symptoms of depression, anxiety, or psychological distress compared to a control group. The majority of participants in the intervention condition who were retained at follow-up engaged with the program, and most of these participants reported satisfaction with the UVC. Discussion The results suggest that multi-component online interventions such as the UVC have utility in a university environment. Future trials of the UVC should examine the impact of guidance and/or tailoring on treatment efficacy, and the potential role of the UVC in a stepped care model incorporating on-campus services.Funding for this project was provided by an Early Career Researcher Award from the Society for Mental Health Research and the Australian Foundation for Mental Health Research (AFFIRM). LMF is supported by a fellowship from the Australian Research Council, DE190101382. PJB is supported by a fellowship from the National Health and Medical Research Council, 1158707application/pdfen-AU© 2019 The Authors.http://creativecommons.org/licenses/BY-NC-ND/4.0/University studentsOnline interventionRandomised controlled trialMental health Transdiagnostic201910.1016/j.invent.2019.1002762023-05-07CC BY-NC-ND license