Aromatic chlorination of ω-phenylalkylamines and ω-phenylalkylamides in carbon tetrachloride and α,α,α-trifluorotoluene

O'Connell, JennySimpson, Jamie SDumanski, PaulSimpson, Gregory WayneEaston, Christopher2015-12-131477-0520http://hdl.handle.net/1885/84967The aromatic halogenation of simple alkylbenzenes with chlorine proceeds smoothly in acetic acid but is much less efficient in less polar solvents. By contrast chlorination of ω-phenylalkylamines, such as 3-phenylpropylamine, occurs readily in either aceKeywords: Acetic acid; Amines; Carbon inorganic compounds; Organic solvents; Rate constants; Alkylbenzenes; O-chloroimidates; Ortho-chlorinated products; Aromatic compounds; alpha,alpha,alpha trifluorotoluene; alpha,alpha,alpha-trifluorotoluene; amide; carbon tetraAromatic chlorination of ω-phenylalkylamines and ω-phenylalkylamides in carbon tetrachloride and α,α,α-trifluorotoluene200610.1039/b605010g2015-12-12