McGrath, Andrew J.Chien, Yi-HsinCheong, SoshanHerman, David A. J.Watt, JohnHenning, Anna M.Gloag, LucyYeh, Chen-ShengTilley, Richard D.2025-05-302025-05-301936-0851PubMed:26549201WOS:000367280100078ORCID:/0000-0001-7548-1521/work/171934940http://www.scopus.com/inward/record.url?scp=84952361276&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733755264Bimetallic nanostructures show exciting potential as materials for effective photothermal hyperthermia therapy. We report the seed-mediated synthesis of palladium-gold (Pd-Au) nanostructures containing multiple gold nanocrystals on highly branched palladium seeds. The nanostructures were synthesized via the addition of a gold precursor to a palladium seed solution in the presence of oleylamine, which acts as both a reducing and a stabilizing agent. The interaction and the electronic coupling between gold nanocrystals and between palladium and gold broadened and red-shifted the localized surface plasmon resonance absorption maximum of the gold nanocrystals into the near-infrared region, to give enhanced suitability for photothermal hyperthermia therapy. Pd-Au heterostructures irradiated with an 808 nm laser light caused destruction of HeLa cancer cells in vitro, as well as complete destruction of tumor xenographs in mouse models in vivo for effective photothermal hyperthermia.A.J.M. and R.D.T. thank the Royal Society of New Zealand for funding under the New Zealand-Taiwan Nanotechnology Research Programme, and the Ministry of Business, Innovation and Enterprise for funding.9enPublisher Copyright: © 2015 American Chemical Society.GoldHyperthermiaNanoparticlesNanostructuresPalladium2015-11-0710.1021/acsnano.5b0556384952361276