Synthesis of [123l] iodine labelled imidazo [1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT

Katsifis, AndrewBarlin, GordonMattner, FDikic, Branko2015-12-132015-12-130033-8230http://hdl.handle.net/1885/80898The pyridazines 3-acetamidomethyl-6-chloro-2-(4′-iodophenyl) imidazo[1,2-b]pyridazine 1 (IC50 = 1.6 nM) and 3-benzanfidomethyl-6- iodo-2-(4′-t-butylphenyl)imidazo[1,2-b] pyridazine 2 (IC50 = 4.2 nM), are high affinity and selective ligands for the PerKeywords: 3 acetamidomethyl 6 chloro 2 (4' iodophenyl)imidazo[1,2 b]pyridazine; 3 acetamidomethyl 6 chloro 2 (4' iodophenyl)imidazo[1,2 b]pyridazine i 123; 3 benzamidomethyl 6 iodo 2 (4' tert butylphenyl)imidazo[1,2 b]pyridazine; 3 benzamidomethyl 6 iodo 2 (4' tert Imidazo[1,2-b]pyridazines; Iodine-123; Iododestannylation; Peripheral benzodiazepine receptors; SPECTSynthesis of [123l] iodine labelled imidazo [1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT200410.1524/ract.92.4.305.355812015-12-11