Matveenko, MariaBanwell, MartinJoffe, MaxWan, SoosanFantino, Emmanuelle2015-12-101612-1872http://hdl.handle.net/1885/55037The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.Keywords: antineoplastic agent; lycoricidine; narciclasine; unclassified drug; antineoplastic activity; article; cancer cell culture; drug cytotoxicity; drug screening; drug synthesis; enantiomer; female; human; human cell; male; Amaryllidaceae Alkaloids; Antineopl200910.1002/cbdv.2008003192016-02-24