Comparative roles of IL-4, IL-13, and IL-4R alpha in dendritic cell maturation and CD4(+) Th2 cell function

Webb, DianneCai, YepingMatthaei, KlausFoster, Paul S2015-12-080022-1767http://hdl.handle.net/1885/31222IL-4 and IL-13 play key roles in Th2 immunity and asthma pathogenesis. Although the function of these cytokines is partially linked through their shared use of IL-4Rα for signaling, the interplay between these cytokines in the development of memory Th2 rKeywords: gamma interferon; interleukin 13; interleukin 4; interleukin 4 receptor alpha; adolescent; allergic disease; animal cell; animal experiment; article; asthma; CD4+ T lymphocyte; cell function; cell maturation; coculture; controlled study; cytokine productiComparative roles of IL-4, IL-13, and IL-4R alpha in dendritic cell maturation and CD4(+) Th2 cell function20072015-12-08