Cloherty, ShaunHietanen, MarkusSuaning, GreggIbbotson, Michael2015-12-08August 31-9781424441242http://hdl.handle.net/1885/32091We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.Keywords: Cortical response; Electrical stimulations; Electrode arrays; General linear models; Intrinsic signal; Linear model; Localized activations; Optical intrinsic signal imaging; Primary visual cortex; Mathematical models; Activation analysis201010.1109/IEMBS.2010.56259992016-02-24