Effect of gating modifier toxins on membrane thickness: Implications for toxin effect on gramicidin and mechanosensitive channels

Chen, RongChung, Shin-Ho2015-12-132072-6651http://hdl.handle.net/1885/71668Various gating modifier toxins partition into membranes and interfere with the gating mechanisms of biological ion channels. For example, GsMTx4 potentiates gramicidin and several bacterial mechanosensitive channels whose gating kinetics are sensitive toAuthor/s retain copyrightKeywords: gramicidin; heteropodatoxin 2; ion channel; MTx4 toxin; toxin; unclassified drug; article; binding affinity; binding site; channel gating; concentration (parameters); drug potentiation; energy transfer; Grammostola spatulata; hydrophilicity; hydrophobicit Gating modifier toxin; Lipid bilayer; Membrane; Molecular dynamicsEffect of gating modifier toxins on membrane thickness: Implications for toxin effect on gramicidin and mechanosensitive channels201310.3390/toxins50204562016-02-24