The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

Hewawasam, RuwaniLiu, DanCasarotto, MarcoDulhunty, AngelaBoard, Philip2015-12-070006-2952http://hdl.handle.net/1885/17374Ca2+ release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RyR2) is essential for heart function and is inhibited by the carboxy terminal domain of glutathione transferase M2-2 (GSTM2-C) and derivative fragments containing helix 6.Keywords: alanine; aspartic acid; calcium ion; glutathione transferase M2; glutathione transferase M2 2; leucine; phenylalanine; tryptophan; tyrosine; unclassified drug; amino acid substitution; article; calcium transport; carboxy terminal sequence; cell vacuole; c Calcium release from cardiac sarcoplasmic reticulum; Calcium release from skeletal sarcoplasmic reticulum; Cardiac RyR2 channels; Glutathione transferase GSTM2-2; Lipid bilayer single channel experiments; Skeletal RyR1 channelsThe structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor201010.1016/j.bcp.2010.04.0192016-02-24