Fang, YiJing, Junmei2015-12-080022-5193http://hdl.handle.net/1885/30417We derive a new continuous free energy formula for protein folding. We obtain the formula first by adding hydrophobic effect to a classical free energy formula for cavities in water. We then obtain the same formula by geometrically pursuing the structureKeywords: globular protein; chemical bonding; enzyme activity; geometry; hydrogen; hydrophobicity; peptide; protein; theoretical study; thermodynamics; article; geometry; hydrogen bond; hydrophobicity; mathematical model; priority journal; protein domain; protein f Area; Constrained minimization; Free energy; Globular protein; Hydrogen bond; Hydrophobic area; Hydrophobic core; Hydrophobic effect; Volume200910.1016/j.jtbi.2009.09.0132016-02-24