Avery, Danielle TEllyard, JuliaMackay, FabienneCorcoran, Lynn MHodgkin, Phillip DTangye, Stuart G2015-12-100022-1767http://hdl.handle.net/1885/49560Plasma cells (PC) or Ig-secreting cells (ISC) are terminally differentiated B cells responsible for the production of protective Ig. ISC can be generated in vitro by culturing human B cells with the T cell-derived stimuli CD40L, IL-2, and IL-10. ISC haveKeywords: CD27 antigen; CD38 antigen; CD40 ligand; interleukin 10; interleukin 2; protein Blimp 1; transcription factor; unclassified drug; X box binding protein 1; antigen expression; article; cell division; cell proliferation; controlled study; human; human cell;Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage20052015-12-09