Gandhi, Neha SFreeman, CraigMancera, Ricardo LParish, Christopher2015-12-100959-6658http://hdl.handle.net/1885/39510Mammalian heparanase is an endo-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparanKeywords: angiogenesis inhibitor; antineoplastic agent; beta glucuronidase; carbohydrate; glucosamine; glucuronic acid; glycosaminoglycan; glycosaminoglycan polysulfate; heparan sulfate; heparanase; heparin derivative; indole; morpholine; pi 88; piperidine; pyridin glycol-split; glycosidase; heparanase; heparin; molecular dynamicsComputational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)201210.1093/glycob/cwr0952016-02-24