Skibola, Christine FBracci, Paige MNieters, AlexanderBrooks-Wilson, Angelade Sanjose, SilviaHughes, Ann MareeCerhan, James RSkibola, Danica RPurdue, MarkKane, EleanorLan, QingForetova, LenkaSchenk, MaryjeanSpinelli, John JSlager, Susan LDe Roos, Anneclaire JSmith, Martyn TRoman, EveCozen, WendyBoffetta, PaoloKricker, AnneZheng, TongzhangLightfoot, TracyCocco, PierluigiBenavente, YolandaZhang, YaweiHartge, PatriciaLinet, Martha SBecker, NikolausBrennan, PaulZhang, LuopingArmstrong, Bruce KSmith, AlexShiao, ReneeNovak, Anne JMaynadie, MarcChanock, Stephen JStaines, AnthonyHolford, Theodore RHolly, Elizabeth ARothman, NathanielWang, Sophia S2015-12-130002-9262http://hdl.handle.net/1885/79086In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF-308A carriers (NHL: per-allele odds ratio (ORallelic)=1.10, Ptrend=0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic=1.23, Ptrend=0.004). In the combined population, odds ratios were increased for TNF-308A carriers (NHL: ORallelic=1.13, Ptrend=0.0001; DLBCL: ORallelic=1.25, Ptrend=3.7 × 10-6; marginal zone lymphoma: ORallelic=1.35, Ptrend=0.004) and LTA 252G carriers (DLBCL: ORallelic=1.12, Ptrend = 0.006; mycosis fungoides: ORallelic=1.44, Ptrend=0.015). The LTA 252A>G/TNF-308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P=2.9 × 10-8). Results suggested associations between IL10-3575T>A and DLBCL (Ptrend=0.02) and IL10-1082A>G and mantle cell lymphoma (Ptrend=0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF-308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.Keywords: caspase recruitment domain protein 15; interleukin 10; lymphotoxin; tumor necrosis factor; ethnic group; etiology; gene expression; health risk; meta-analysis; protein; toxin; tumor; adult; article; controlled study; ethnicity; female; genetic variability Lymphoma; Lymphoma, non-Hodgkin; Lymphotoxin-alpha; Meta-analysis; Polymorphism, genetic; Polymorphism, single nucleotide; Tumor necrosis factor-alphaTumor necrosis factor (TNF) and lymphotoxin-a (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium201010.1093/aje/kwp3832016-02-24