Cherbuin, NicolasLeach, LianaChristensen, HelenAnstey, Kaarin2015-12-081420-8008http://hdl.handle.net/1885/32343Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematicallyKeywords: apolipoprotein E; glucose; allele; Alzheimer disease; amygdaloid nucleus; brain atrophy; brain blood flow; brain function; brain size; brain ventricle; cognitive defect; degenerative disease; disease course; Doppler echography; entorhinal cortex; genetic Alzheimer's disease; Apolipoprotein E; Braak stages; Cognitive aging; Magnetic resonance imaging200710.1159/0001091502015-12-08