Martin, StephenGoodnow, Christopher2015-12-131529-2908http://hdl.handle.net/1885/94594The basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversible molecular change in the B cell antigen receptor, which is brought about by immunoglobulin M (IgM) toKeywords: B lymphocyte receptor; immunoglobulin G; immunoglobulin M; animal cell; animal experiment; animal tissue; antibody response; antigen specificity; article; B lymphocyte; cell count; controlled study; immunological memory; in vivo study; lymphocyte prolifer200210.1038/ni7522015-12-12