Van Kerkhove, Maria D.Asikainen, TommiBecker, Niels G.Bjorge, StevenDesenclos, Jean-Claudedos Santos, ThaisFraser, ChristopheLeung, Gabriel M.Lipsitch, MarcLongini, Ira M.McBryde, Emma S.Roth, Cathy E.Shay, David K.Smith, Derek J.Wallinga, JaccoWhite, Peter J.Ferguson, Neil M.Riley, Steven2015-11-302015-11-301549-1676http://hdl.handle.net/1885/16912In light of the 2009 influenza pandemic and potential future pandemics, Maria Van Kerkhove and colleagues anticipate six public health challenges and the data needed to support sound public health decision making.The authors acknowledge support from the Bill & Melinda Gates Foundation (MDVK, CF, NMF); Royal Society (CF); Medical Research Council (MDVK, CF, PJW, NMF); EU FP7 programme (NMF); UK Health Protection Agency (PJW); US National Institutes of Health Models of Infectious Disease Agent Study program through cooperative agreement 1U54GM088588 (ML); NIH Director's Pioneer Award, DP1-OD000490-01 (DS); EU FP7 grant EMPERIE 223498 (DS); the Wellcome Trust (DS); 3R01TW008246-01S1 from Fogerty International Center and RAPIDD program from Fogerty International Center with the Science & Technology Directorate, Department of Homeland Security (SR); and the Institut de Veille Sanitaire Sanitaire funded by the French Ministry of Health (J-CD). The funders played no role in the decision to submit the article or in its preparation.This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.biomedical researchdecision makinghumansinfluenza, humanpublic healthseverity of illness indexinfluenza a virus, h1n1 subtypemodels, biologicalpandemics2010-06-0110.1371/journal.pmed.10002752015-12-08