Kumar, RajeevGunaratne, DharshanieKhan, SalmanCrawford, KerryCook, MatthewTuck, Roger2014-02-212014-02-211039-8562http://hdl.handle.net/1885/11405Autoimmune limbic encephalitis (ALE) is a well-characterized neuropsychiatric syndrome with associated neuroimaging and immunological diagnostic markers.1 Importantly, because of the predominant psychiatric symptoms in a majority of patients, most patients are seen initially by psychiatrists.2 Immune-mediated encephalitis can be paraneoplastic and several antibodies to onconeural antigens have been identified.3 A relatively new clinical subsyndrome of ALE has been identified in young women, often associated with antibodies to the N-methyl-D-aspartate receptor (NMDAR) and usually with a set of striking clinical features, including changes in personality, mood and anxiety symptoms, psychosis, bizarre behavior and catatonia.2,4 Although more than 50% of cases are associated with a tumor, especially ovarian teratoma, there are cases where no such association could be demonstrated, especially in younger patients.2,5 The characteristic clinical features of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are a prodromal flu-like illness followed by a range of psychiatric, neurological and autonomic symptoms and signs.4,6 (Taken from first paragraph).2 pageshttp://www.sherpa.ac.uk/romeo/issn/1039-8562/author can archive pre-print (ie pre-refereeing);author can archive post-print (ie final draft post-refereeing); author cannot archive publisher's version/PDF (Sherpa/Romeo as at 21/2/14)acuteneuropsychiatricmanifestationsautoimmune limbic encephalitis (ALE)anti-N-methyl-D-aspartate receptor encephalitis2013-05-2910.1177/10398562134761222016-06-14