Natoli, RiccardoFernando, NilishaDahlenburg, TessJiao, HaihanAggio-Bruce, RiemkeBarnett, Nigel L.Chao De La Barca, JuanTcherkez, GuillaumeReynier, PascalChu-Tan, JoshuaValter, KrisztinaProvis, JanRutar, Matthew2019-07-122019-07-121090-0535http://hdl.handle.net/1885/164546Purpose Systemic increases in reactive oxygen species, and their association with inflammation, have been proposed as an underlying mechanism linking obesity and age-related macular degeneration (AMD). Studies have found increased levels of oxidative stress biomarkers and inflammatory cytokines in obese individuals; however, the correlation between obesity and retinal inflammation has yet to be assessed. We used the leptin-deficient (ob/ob) mouse to further our understanding of the contribution of obesity to retinal oxidative stress and inflammation.This study was supported by an Australian Government Research Training Program (RTP) Scholarship.application/pdfen-AU© 2018 Molecular Vision © The Author(s) 2018http://creativecommons.org/licenses/by-nc-nd/3.0/Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment20182019-03-31Creative Commons Attribution-NonCommercial-NoDerivatives License 3.0