Beckman, MarieFreeman, CraigSmall, David HParish, Christopher2015-12-081742-464Xhttp://hdl.handle.net/1885/34484We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer's β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to BKeywords: amino acid; cathepsin D; enzyme precursor; glycosaminoglycan; heparin; procathepsin d; sulfate; unclassified drug; amino acid sequence; article; catalysis; controlled study; drug potency; enzyme activation; enzyme active site; enzyme activity; enzyme regu Aspartic protease; Cathepsin D; Glycosaminoglycan; Heparin; Proteolytic activity200910.1111/j.1742-4658.2009.07444.x2016-02-24