Gehring, W. J.Müller, M.Affolter, M.Percival-Smith, A.Billeter, M.Qian, Y. Q.Otting, G.Wüthrich, K.2026-03-012026-03-010168-9525PubMed:1980756ORCID:/0000-0002-0563-0146/work/206892047https://hdl.handle.net/1885/733806827The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.7en199010.1016/0168-9525(90)90253-30025008350