Ecroyd, HeathCarver, John2015-12-101420-682Xhttp://hdl.handle.net/1885/63182Improper protein folding (misfolding) can lead to the formation of disordered (amorphous) or ordered (amyloid fibril) aggregates. The major lens protein, α-crystallin, is a member of the small heat-shock protein (sHsp) family of intracellular molecular cKeywords: alpha crystallin; alpha synuclein; amyloid; amyloid beta protein[25-35]; beta crystallin; biomaterial; chaperone; gamma crystallin; heat shock protein 20; heat shock protein 25; heat shock protein 27; small heat shock protein; Alzheimer disease; amino aci Alzheimer's disease; Amyloid fibril; Cataract; Crystallin; Lens; Molecular chaperone; Parkinson's disease; Protein aggregation; Protein folding; Small heat-shock protein200910.1007/s00018-008-8327-42016-02-24