A chemoenzymatic total synthesis of the structure assigned to the alkaloid (+)-montabuphine

Matveenko, MariaBanwell, MartinWillis, Anthony2015-12-101523-7060http://hdl.handle.net/1885/52498(Chemical Equation Presented) An enantioselective synthesis of the structure, 3, assigned to the alkaloid (+)-montabuphine has been achieved using the readily available metabolite 4 as starting material. A comparison of the physical and spectral data recorded on compound 3 with those reported for (+)-montabuphine suggests that they are different compounds.Keywords: alkaloid; Amaryllidaceae alkaloid; enzyme; montabuphine; unclassified drug; article; chemical structure; chemistry; metabolism; nuclear magnetic resonance spectroscopy; synthesis; Alkaloids; Amaryllidaceae Alkaloids; Enzymes; Magnetic Resonance SpectroscoA chemoenzymatic total synthesis of the structure assigned to the alkaloid (+)-montabuphine200810.1021/ol801815k2016-02-24