Bertram, EdwardDawicki, WojcieckWatts, Tania H.2015-12-132015-12-131044-5323http://hdl.handle.net/1885/78310Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.Keywords: B7 antigen; CD134 antigen; CD137 antigen; CD27 antigen; CD28 antigen; CD4 antigen; CD40 antigen; CD40 ligand; CD70 antigen; immunoglobulin M; inducible costimulator protein; interleukin 2; major histocompatibility antigen class 1; protein; T lymphocyte re CD28 family; Costimulation; DLN; draining lymph node; T cells; thymidine kinase; TIM; TK; TNF receptor associated factor; TNFR; TNFR family; TRAF; TRAF interacting motif; tumor necrosis factor receptor; Viruses200410.1016/j.smim.2004.02.0062015-12-11