Growth factor TGF- β induces intestinal epithelial cell (IEC-6) differentiation: MiR-146b as a regulatory component in the negative feedback loop

Liao, YalinZhang, ManLonnerdal, Bo2015-12-131865-3499http://hdl.handle.net/1885/74245TGF-β is a potent pleiotropic factor that promotes small intestinal cell differentiation. The role of microRNAs in the TGF-β induction of intestinal epithelial phenotype is largely unknown. We hypothesized that microRNAs are functionally involved in TGFKeywords: alkaline phosphatase; microRNA; microRNA 146b; microsomal aminopeptidase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; protein SIAH2; Smad7 protein; transforming growth factor beta; ubiquitin protein ligase E3; unclassified drug Differentiation; IEC-6 cell; microRNA array; miR-146b; SIAH2; TGF-ßGrowth factor TGF- β induces intestinal epithelial cell (IEC-6) differentiation: MiR-146b as a regulatory component in the negative feedback loop201310.1007/s12263-012-0297-32016-02-24