Bodkin, Jennifer AHumphries, EdwardMcLeod, Malcolm2015-12-100040-4039http://hdl.handle.net/1885/56725Careful control during the bromolactonisation of β,γ-unsaturated acid 3 was required to afford regioselectively the trans-β-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipaKeywords: acid; lactone derivative; tetrahydrolipstatin; article; bromolactonization; chemical reaction; debromination; diastereoisomer; drug synthesis; proton nuclear magnetic resonance; stereochemistry ß-lactone; (-)-tetrahydrolipstatin; Bromolactonisation; Radical dehalogenation200310.1016/S0040-4039(03)00443-X2015-12-09