Magalhães, Ricardo J.Langa, AntonioSousa-Figueiredo, JoséClements, Archie CANery, Susana2016-01-062016-01-061475-2875http://hdl.handle.net/1885/95295BACKGROUND Identifying and targeting hyper-endemic communities within meso-endemic areas constitutes an important challenge in malaria control in endemic countries such like Angola. Recent national and global predictive maps of malaria allow the identification and quantification of the population at risk of malaria infection in Angola, but their small-scale accuracy is surrounded by large uncertainties. To observe the need to develop higher resolution malaria endemicity maps a predictive risk map of malaria infection for the municipality of Dande (a malaria endemic area in Northern Angola) was developed and compared to existing national and global maps, the role of individual, household and environmental risk factors for malaria endemicity was quantified and the spatial variation in the number of children at-risk of malaria was estimated. METHODS Bayesian geostatistical models were developed to predict small-scale spatial variation using data collected during a parasitological survey conducted from May to August 2010. Maps of the posterior distributions of predicted prevalence were constructed in a geographical information system. RESULTS Malaria infection was significantly associated with maternal malaria awareness, households with canvas roofing, distance to health care centre and distance to rivers. The predictive map showed remarkable spatial heterogeneity in malaria risk across the Dande municipality in contrast to previous national and global spatial risk models; large high-risk areas of malaria infection (prevalence >50%) were found in the northern and most eastern areas of the municipality, in line with the observed prevalence. CONCLUSIONS There is remarkable spatial heterogeneity of malaria burden which previous national and global spatial modelling studies failed to identify suggesting that the identification of malaria hot-spots within seemingly mesoendemic areas may require the generation of high resolution malaria maps. Individual, household and hydrological factors play an important role in the small-scale geographical variation of malaria risk in northern Angola. The results presented in this study can be used by provincial malaria control programme managers to help target the delivery of malaria control resources to priority areas in the Dande municipality.This work was funded by the promoters of the CISA Project (Portuguese Institute for Development Assistance, Calouste Gulbenkian Foundation, Bengo Provincial Government and the Ministry of Health of Angola). RJSM is supported by a UQ Postdoctoral Research Fellowship and ACAC is supported by a NHMRC Career Development Fellowship.© 2012 Magalhães et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.adolescentadultagedaged, 80 and overangolachildchild, preschoolcross-sectional studiesepidemiologic studiesfamily characteristicsfemalehumansinfantmalariamalemiddle agedprevalencerisk assessmentyoung adultendemic diseasestopography, medical2012-11-2210.1186/1475-2875-11-3852016-06-14