Karyotaki, EiriniRiper, HTwisk, JosHoogendoorn, AdriaanKleiboer, Annet M.Mira, AdrianaMackinnon, AndrewMeyer, BjörnBotella, CristinaLittlewood, ElizabethAndersson, GerhardChristensen, HelenKlein, Jan P.Schröder, JohannaBretón-López, JuanaScheider, JustineGriffiths, KathleenFarrer, LouiseHuibers, Marcus J HPhillips, RachelGilbody, SimonMoritz, SteffenBerger, ThomasPop, VictorSpek, ViolaCuijpers, Pim2021-06-112168-622Xhttp://hdl.handle.net/1885/237284Many studies have found that depressive symptoms can be effectively treated with psychotherapy, pharmacotherapy, or both. Nevertheless, many people with depressive symptoms do not seek help, and even well-resourced health care systems find it difficult to marshal enough qualified therapists to offer psychological interventions. Access barriers to psychotherapy include limited availability of trained clinicians, high cost of treatment, and fear of stigmatization. As a consequence, a significant number of individuals with depressive symptoms remain untreatedThis work was performed under grant 603098 for the European Comparative Effectiveness Research on Internet-based Depression Treatment (E-COMPARED) project funded by the European Commission’s Seventh Framework Program. At the time of the study, Dr Griffiths was supported by National Health & Medical Research Council Fellowship 1059620.application/pdfen-AU© Copyright 2017 American Medical Association201710.1001/jamapsychiatry.2017.00442020-11-23