Jackson, KerrieBanwell, MartinHarfoot, GwionWillis, Anthony2015-12-130040-4039http://hdl.handle.net/1885/85137Formal total syntheses of the natural enantiomeric forms of the title sesquiterpenes 1 and 2 have been achieved using, as starting material, the readily available and enantiomerically pure cis-1,2-dihydrocatechol 4 derived from the whole-cell biotransformation of toluene.Keywords: complicatic acid; hirsutene; hirsutic acid; sesquiterpene derivative; toluene; unclassified drug; article; biotransformation; chemical modification; enantiomer; enzyme synthesis; reaction analysis; Betulaceae (-)-Complicatic acid; Chemoenzymatic; cis-1,2-Dihydrocatechol; Diels-Alder reaction; Sesquiterpene; Triquinane200610.1016/j.tetlet.2006.07.1452015-12-12