Doszt�nyi, ZsuzsannaTorda, Andrew2015-12-101367-4803http://hdl.handle.net/1885/66536Motivation: We propose a general method for deriving amino acid substitution matrices from low resolution force fields. Unlike current popular methods, the approach does not rely on evolutionary arguments or alignment of sequences or structures. Instead,Keywords: amino acid; protein; amino acid sequence; amino acid substitution; article; controlled study; energy; mathematical computing; methodology; mutation; philosophy; priority journal; scoring system; sequence analysis; Amino Acid Substitution; Chemistry, Physi20012015-12-10